A few years ago, motivated by a family history of dementia, Bea Pena-Reames began using a dietary supplement that promised improved memory and brain health. It was advertised as safe and effective – but that was not her experience.

“I’m typically a joyful person, but I couldn’t shake this depression and intense sense of sadness,” said Pena-Reames, 56, a former high school biology teacher who lives in north Texas. “I was getting angry at the drop of a hat.”

Loosely regulated dietary supplements of the sort Pena-Reames took have found a rich vein of acceptance among middle-age and older Americans increasingly worried about losing their mental acuity.

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